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KMID : 0606319990160010013
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Journal of Phamacetical Sciences Sookmyung Women s University
1999 Volume.16 No. 1 p.13 ~ p.31
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Development and Studies of Platinum Complexes as Autitumor Agent
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Whang Kyu-Ja
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Abstract
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Since the discovery of antitumor activity of cisplatin by Rogenberg in 1969, various Pt complexes were prepared in order to decrease toxicity and to increase water-solubility. Carboplatin has good water solubility and low nephrotoxicity as a 2nd generation antitumor agent. But it has narrow antitumor spectrum and cross-cisplatin resistance. Other various platinum complexes were synthesized, with an aim to have high and specific antitumor activity without or least toxicity. The interaction of Pt complexes with DNA have been found to mainly intrastrand crosslinking at N-7 of guanine base. Demonstration of correlation between anticancer drugs and the cell cycle may be useful in chemotherapeutic design. In the future, development of platinum complexes must be focused overcoming of limited antitumor spectrum, cisplatin-resistant cell inhibition and less toxicity.
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